The briefing
Researchers identified genes regulating experience-dependent plasticity in hippocampal parvalbumin-expressing interneurons and showed that upregulating Meis2 in adulthood restored this plasticity in a neurodevelopmental disorder mouse model. The intervention improved memory and network function and reduced seizures, suggesting adult-targeted therapies could reverse developmental circuit deficits.
Original headline
Procognitive restoration of PV neuron plasticity in neurodevelopmental disorders