The briefing
Researchers integrated bulk and single-cell RNA sequencing across 33 cancers and found NUPR1 dysregulation with prognostic significance. The gene correlates with genomic instability and immune infiltration, is enriched in epithelial cells and macrophages, and its inhibition in breast cancer cells showed anticancer and radiosensitizing effects.
Original headline
Integration of bulk and single-cell RNA sequencing analyses elucidates the role of NUPR1 in tumour microenvironment and cancer development