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Biocatalytic cascade delivers chiral oxazolidinones from simple alkenes

Biocatalytic cascade delivers chiral oxazolidinones from simple alkenes

A haemprotein-catalyzed aziridination and ring-expansion enables direct, enantioselective synthesis of oxazolidinones from unactivated alkenes. The approach advances nitrene-transfer chemistry and could aid discovery of next‑generation antibiotic scaffolds.

Original headline

Chiral oxazolidinones via biocatalytic aziridination of unactivated alkenes

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