The briefing
A Nature study evaluating BAP1, MTAP and 5-hmC immunohistochemical markers found that while each has moderate sensitivity alone, using them together markedly improves detection of pleural mesothelioma. In the reported cohort, the combination reached high sensitivity with perfect specificity versus benign controls, supporting an algorithm that starts with BAP1 to diagnose most cases.
Original headline
Evaluation of BAP1, MTAP, and 5-HMC as diagnostic markers in pleural mesotheliomas