Neonatal Bilirubin Trajectories Tied to Adverse Outcomes, But Validation Falls Short

The briefing

A two‑database cohort analysis modeled early‑life bilirubin trajectories and linked high‑risk patterns to outcomes including death, necrotizing enterocolitis, and late‑onset sepsis. The approach did not outperform peak bilirubin in one database and failed external validation in another, suggesting trajectories may reflect underlying immaturity and illness.